Does NAD Help With Sleep?

More than ever, people are aware of their health and are striving to improve themselves. There has been a growing interest in NAD+ injections and capsules (nicotinamide adenine dinucleotide) as a way to increase the levels of this important coenzyme for health, ageing and energy.

The issue of having enough energy during the day and being overall healthier is linked closely to sleep. According to a report by Mental Health UK, nearly 1 in 5 people in this country aren’t getting enough sleep.

Now, there’s a lot of information out there about how to get better sleep, including taking medication. However, as we become more health-conscious, an increasing number of people in the UK are looking to improve naturally.

So, does NAD help with sleep? What are the benefits of these NAD and does the science back up the claims? Let’s find out…

What Is NAD+?

NAD is a coenzyme found in cells throughout the body. This coenzyme plays an important role in your body functioning efficiently and is involved in multiple metabolic processes. Everything you need to know about NAD+ can be found here, but let’s boil it down to 3 things it does:

The Link Between NAD+ and Sleep

Circadian Rhythm

NAD+ and circadian rhythm are closely linked. Your circadian rhythm is your body’s 24-hour internal clock, helping it function on a healthy sleep-wake cycle.

NAD+ can influence your body clock through sirtuins, proteins we’ve already talked about, but especially SIRT1. This protein plays a key role in your SCN (suprachiasmatic nucleus), the part of your brain where your circadian rhythm originates.

Mitochondrial Health

Mitochondria are the power source of cells. NAD in the body helps protect the mitochondria from oxidative stress and is involved in many redox reactions, helping with mitochondrial function and cellular health.

When you sleep, the mitochondria help your body repair itself. To function efficiently, the mitochondria need good NAD+ levels.

Ageing and NAD+

NAD+ naturally declines as you age. As your SCN functionality declines, your circadian rhythm becomes more disrupted, resulting in less sleep of good quality.

With lower NAD+, you may also have more stress and experience more fatigue and cellular damage – which all can contribute to poorer sleep quality.

Scientific Research & Theoretical Insights

There is emerging science to suggest that NAD+ has an important role in biological clocks. One study from 2021 concluded that NAD+ was essential in energy metabolism and circadian rhythm function.

Another from 2024 found that NAD+ supplements have the potential to relieve chronic sleep restriction (CSR)-induced issues such as memory loss and cognitive decline.

Melatonin

Another important aspect of sleep quality is melatonin. This is a hormone we produce naturally that helps to regulate our sleep-wake cycle. If your circadian rhythm is disrupted, then so is your melatonin production.

Sleep Architecture

Your sleep architecture is the different stages of your sleep. NAD+ is involved in various biological processes that can influence your sleep. A 2023 study suggested that restoring NAD+ levels through supplements could reduce the need for sleep.

Can NAD+ Therapy Improve Sleep?

NAD+ IV therapy for sleep is when NAD+ is administered intravenously. Studies have found that NAD+ will play a key role in regenerative medicine in the future. As explained above, there are studies that support the idea that NAD+ supplements can help with sleep improvement. A study in 2022 found that NAD+ IV therapy might improve sleep duration and quality.

While research into NAD+ IV therapy for sleep is in its early stages, many people who engage in the treatment are big fans. Celebrities such as Jennifer Aniston, Bella Hadid and former NFL quarterback Jay Cutler have all talked about NAD+ therapy and its benefits.

Besides potential sleep improvements, other indirect effects that some people reported include:

Despite all the benefits, it’s important to note that NAD+ is not a direct sleep aid like melatonin. NAD+ is a cellular optimiser, helping your body work more efficiently.

Who Might Benefit from NAD+ for Sleep?

Everyone could benefit from a better night’s sleep. However, there are some people in particular who may truly benefit from a little NAD+ boost to help them start the journey to improving their sleep and overall well-being.

Brain Fog, Fatigue and Poor Sleep Sufferers

If you are suffering from fatigue, brain fog, or sleep disturbances, then it might be time to look into NAD+. Sufferers of these issues have usually tried everything, and there is science backing that NAD+ might be helpful to you.

Ageing Adults

NAD+ levels naturally reduce with age, no matter how healthy you are. NAD+ supplements aim to help you maintain levels to stop any further decline and bring out more negative effects.

Biohackers

If you are in the biohacking world, then you’ve probably heard of NAD+. Many people aren’t, but are health-conscious, looking for more natural but evidence-based solutions that can help them optimise their health and performance. If you are an athlete, fitness enthusiast, or burgeoning biohacker, then NAD+ can help optimise your sleep, as well as your waking hours.

Other Benefits That Support Better Sleep

Many other benefits of NAD+ can help with your sleep, including:

Reduced Inflammation

Chronic inflammation can disrupt sleep and sleep quality, whilst sleep deprivation can also contribute to poor sleep. Inflammation triggers the release of cytokines, chemical messengers that can stop you from sleeping well. NAD+ can contribute in regulating cytokine activity, relieving pain and fatigue that are disrupting sleep.

Enhanced Energy

More energy may sound like you’d spend less time sleeping. Increased NAD+ levels can mean that you have more energy during the day, when you need it, which will lead you to do more.

Increased activity will help you become more naturally tired so that you get a better night’s sleep. With less drowsiness during the day and reduced energy, it can be easier to maintain a healthy sleeping pattern.

Improved Stress Regulation

NAD+ is involved in cellular processes related to stress biology, which might mean the difference between a good night’s sleep and a bad night’s sleep.

Experience the Benefits of NAD+ At Home

You don’t have to go all the way to NAD therapy in London or anywhere else to gain the benefits. If you’re looking for an alternative option for improved sleep, more energy and pain and ache reduction, try the NAD+ injection pen.

For more information about NAD+ and our range of wellness products, take a look at our online shop today.