Are NAD+ Injections Safe for Long-Term Use?

NAD+ injection supplements have become a more popular choice in the last few years for those interested in supporting daily health routines. They are not seen as quick fixes, but something to incorporate into your life; naturally, people wonder whether repeated NAD+ injections can be used safely over months or years.

So, are NAD+ injections safe long term?

There is nothing to suggest they are not. Recent studies have looked at NAD+ IV therapy and short-term outcomes, but research into examining the long-term use of repeated subcutaneous NAD+ injections in humans remains limited at the moment.

Before bringing NAD+ injections into your health routine, it might be worth speaking to a qualified healthcare professional to ensure your suitability and safety for these types of supplements.

What Are NAD+ Injections?

NAD+ (Nicotinamide Adenine Dinucleotide) is a naturally occurring enzyme that is in every cell in your body, involved in a wide range of processes, particularly cellular metabolism and cell energy production.

Levels naturally decrease as you age, so boosting them with supplements is believed to have many benefits for your everyday functioning.

NAD+ supplements come in many forms. NAD+ injections refer to self-administered subcutaneous injections, injected into the layer of fat between the skin and muscle for effortless and convenient supplementation.

Other options include IV therapy, where you have to go to a clinic and have a professional infuse NAD+ directly into your bloodstream from a drip over a few hours. Another common supplement option is oral NAD+ products that are usually NAD+ precursors such as NR or NMN, which you swallow and your body turns into NAD+.

Because there are different methods, formulations and approaches, looking at the specific evidence concerning one substance or delivery method does not automatically mean that another one is safe too.

What Does “Long-Term Use” Mean?

When talking about long-term use, we usually mean repeated administration or use of a supplement over several months or years. If you are using something for the long term, it has become part of your routine.

The safety of any supplement or lifestyle change depends on many factors. When it comes to NAD+ and other supplements, you need to consider the dose, frequency of supplementation, formulation, administration method and your health.

When thinking about these things, it’s key to remember that everyone is different. There is no single supplement schedule that is perfect for everyone. You have to find the safest and most effective path forward for you.

What Does the Research Say About Long-Term Safety?

Interest in NAD+ as a wellness product has grown in recent years, so research around direct NAD+ administration is still a developing area. Most research has looked at the effects of NAD+ in animals (mainly mice), and any human studies have largely focused on small groups in short observation periods and around intravenous delivery.

One study looking at the safety of an injectable form of nicotinamide riboside found that subcutaneous injections were not painless but tolerable, and no serious adverse effects were reported. So far, studies have focused only on short-term tolerability, and the available data cannot assess the safety of repeated NAD+ injections over months and years.

While there have been more studies into oral NAD+ precursors and their uses, this research does not translate to injectable NAD+, as you are looking at different formulas and delivery methods.

Currently, there is nothing to suggest a significant safety concern from injectable NAD+ products, but further controlled, longer-duration studies are needed to confirm this.

What Are the Potential Risks of Repeated NAD+ Injections?

Though NAD+ injections are safe for the majority of people, there is always the potential for someone to experience side effects.

Potential risks of repeated injections include:

A more typical effect of repeated injections may be some local irritation around the injection area. This can happen with any type of injection.

To reduce the risks, you should always ensure the product is sterile, the needle you’re using is clean and sterile, and you are storing the formula correctly in the fridge and handling everything with gloves to avoid contamination.

If you begin to experience unexpected systemic (symptoms away from the injection site) or allergic reactions, then you should stop using the supplement and get a medical assessment.

Who Should Seek Medical Advice Before Using NAD+ Injections?

Though NAD+ supplements are thought to be safe for healthy adults, there are situations where you should first seek out professional advice before using wellness injection products.

You should consult a healthcare professional first if:

Even if you get the all-clear from a medical professional to proceed, this is no guarantee that you won’t experience adverse side effects.

Does Naturally Occurring Mean Safe?

Even though NAD+ is naturally present in your body, that does not mean that repeated injected doses come without risk.

Endogenous (produced in the body) substances are created, processed and regulated by your biology, whereas injection supplements are concentrated formulas coming into your body in a different way, bypassing your bodily filters.

Too much of a good thing can be bad for you, so it’s important that when looking at injectable wellness products, you look beyond the marketing. Don’t just see the word “natural” and believe everything is above board. Instead, use clinical evidence, look at how the products are quality controlled and consult professional guidance before deciding.

How Can Users Approach Long-Term Use Responsibly?

You should approach any change to your health routine responsibly.

Firstly, you should speak to an appropriate healthcare professional and get an assessment to ensure you are suitable to safely use NAD+ injections on a regular basis. It is also worth engaging in periodic reviews so you can check that everything is okay and you’re not reacting badly to the injections.

Other steps you should take include:

Above all, you need to remember that injectable wellness products should be a part of your health routine. You should continue to focus on utilising evidence-based healthcare and healthy lifestyle habits to improve your health and wellbeing.

When Should You Stop and Seek Help?

You should stop using NAD+ injections if you begin to experience:

If you also start suffering from new or unexplained systemic symptoms such as chills, fatigue, or body aches, then you should stop using supplements.

There may be a case when you require immediate medical attention, in particular if you believe you are suffering from a severe allergic reaction. Signs to look out for include:

If your symptoms suggest an emergency, do not wait and call 999 immediately for urgent medical care.

Understanding NAD+ At Home’s Product Options

NAD+ At Home has a range of products, including NAD+ supplements suitable for those who want an easy way to integrate supplements into their life.

We offer NAD+ injection kits and an NAD+ injection pen product for fast and simple NAD+ delivery in your own home, without needing to visit a clinic. Also, we have non-injectable products, such as our Liposomal NAD+ Capsules for those who may not be too fond of needles.

If you are interested in any of our products, please take the time to review the individual product information and don’t assume that every delivery method has the same effects, risks or evidence.

Curious About NAD+ Injections? Explore NAD+ at Home

NAD+ injections are safe and can easily become part of your health and wellness routine. It’s important to be safe, though and don’t assume anything, so take the time to dig into products, ask questions, review safety information and seek out medical advice before beginning or continuing long-term use.

If you have any questions about our NAD+ At Home products, head over to our FAQ page to see if we’ve already answered it.

Still have questions? Contact us via our website or call 0203 824 2840 to speak to one of the team today.