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NAD+

Does NAD Help With Sleep?

Georgina Glenn, Registered Nurse • June 27th 2025

More than ever, people are aware of their health and are striving to improve themselves. There has been a growing interest in NAD+ (nicotinamide adenine dinucleotide) an important coenzyme that is found in everyone – and is important for your health, ageing and energy.

The issue of having enough energy during the day and being overall healthier is linked closely to sleep. According to a report by Mental Health UK, nearly 1 in 5 people in this country aren’t getting enough sleep.

Now, there’s a lot of information out there about how to get better sleep, including taking medication. However, as we become more health-conscious, an increasing number of people in the UK are looking to improve naturally.

So, does NAD help with sleep? What are the benefits of these NAD and does the science back up the claims? Let’s find out…

What Is NAD+?

NAD is a coenzyme that you can find in every living cell. This coenzyme is vital to your body functioning efficiently and is involved in hundreds of metabolic processes. Everything you need to know about NAD+ can be found here, but let’s boil it down to 3 things it does:

Energy production: NAD is vital for energy production in the body. It helps convert the food you eat into energy and supports the mitochondria in producing ATP (adenosine triphosphate). These molecules are the main energy source for cells.
DNA repair: As you go through life, your DNA gets damaged and needs repairing. NAD+ helps with the activation of sirtuins, types of proteins that protect your cells, repair DNA and regulate the ageing process.
Cell Communication: NAD+ is the great messenger in the body. It is vital for ferrying electrons between cells, being the energy for metabolic processes and is a sensor for cellular health, helping important cells talk to each other and start working together.

The Link Between NAD+ and Sleep

Circadian Rhythm

NAD+ and circadian rhythm are closely linked. Your circadian rhythm is your body’s 24-hour internal clock, helping it function on a healthy sleep-wake cycle.
NAD+ can influence your body clock through sirtuins, proteins we’ve already talked about, but especially SIRT1. This protein plays a key role in your SCN (suprachiasmatic nucleus), the part of your brain where your circadian rhythm originates.
To function properly, SIRT1 needs NAD, so increased NAD+ will result in more SIRT1 activity.

Mitochondrial Health

Mitochondria are the power source of cells. NAD in the body helps protect the mitochondria from oxidative stress and is involved in many redox reactions, helping with mitochondria function and cellular health.
When you sleep, the mitochondria help your body repair itself. To function efficiently, the mitochondria need good NAD+ levels.

Ageing and NAD+

NAD+ naturally declines as you age. As your SCN functionality declines, your circadian rhythm becomes more disrupted, resulting in less sleep of good quality. With lower NAD+ you may also have more stress and experience more fatigue and cellular damage – which all can contribute to poorer sleep quality.

Scientific Research & Theoretical Insights

There is emerging science to back up the claims of NAD+ involvement in biological clocks. One study from 2021 concluded that NAD+ was essential in energy metabolism and circadian rhythm function.

Another from 2024 found that NAD+ supplements relieved chronic sleep restriction (CSR)-induced issues such as memory loss and cognition.

Melatonin

Another important aspect of sleep quality is melatonin. This is a hormone we produce naturally that helps to regulate our sleep-wake cycle. If your circadian rhythm is disrupted, then so is your melatonin production.

Sleep Architecture

Your sleep architecture is the different stages of your sleep. NAD+ is involved in various biological processes that influence your sleep architecture. A study from 2023 suggested that restoring NAD+ levels through supplements could help improve your sleep architecture.

Can NAD+ Therapy Improve Sleep?

NAD+ IV therapy for sleep is when NAD+ is administered intravenously. Studies have found that NAD+ will play a key role in regenerative medicine in the future. As explained too, there are studies to support that NAD+ supplements can help with sleep improvement. A study in 2022 found that NAD+ IV therapy could improve sleep duration and quality.

While research into NAD+ IV therapy for sleep is in its early stages, many people who engage in the treatment are big fans. Celebrities such as Jennifer Aniston, Bella Hadid and former NFL quarterback Jay Cutler have all talked about NAD+ therapy and its benefits.

Besides potential sleep improvements, other indirect effects include:

Reduced fatigue
Better stress response
Improved mood

Despite all the benefits, it’s important to note that NAD+ is not a direct sleep aid like melatonin. NAD+ is a cellular optimiser, helping your body work more efficiently.

Who Might Benefit from NAD+ for Sleep?

Everyone could benefit from a better night’s sleep. However, there are some people in particular who may truly benefit from a little NAD+ boost to help them start the journey to improving their sleep and overall well-being.

Brain Fog, Fatigue and Poor Sleep Sufferers

If you are suffering from fatigue, brain fog, or sleep disturbances, then it might be time to turn to NAD+. Sufferers of these issues have usually tried everything, and there is science backing that NAD+ might be helpful to you.

Ageing Adults

NAD+ levels naturally reduce with age, no matter how healthy you are. NAD+ supplements can help you maintain levels to stop any further decline and bring out more negative effects.

Biohackers

If you are in the biohacking world, then you’ve probably heard of NAD+. Many people aren’t, but are health-conscious, looking for more natural but evidence-based solutions that can help them optimise their health and performance. If you are an athlete, fitness enthusiast, or burgeoning biohacker, then NAD+ can help optimise your sleep, as well as your waking hours.

Other Benefits That Support Better Sleep

Many other benefits of NAD+ can help with your sleeping, including:

Reduced Inflammation

Chronic inflammation can disrupt sleep and sleep quality, whilst sleep deprivation can also contribute to poor sleep. Inflammation triggers the release of cytokines, chemical messengers that can stop you from sleeping well. NAD+ can help reduce inflammation in the brain and body by regulating cytokine activity, helping to relieve pain and fatigue that is disrupting sleep.

Enhanced Energy

More energy may sound like you’d spend less time sleeping. Increased NAD+ levels will help you have more energy during the day, when you need it, which will lead you to do more. Increased activity will help you become more naturally tired so that you get a better night’s sleep. With less drowsiness in the day and reduced energy, it’ll be easier to maintain a healthy sleeping pattern.

Improved Stress Regulation and Mood

NAD+ helps balance neurotransmitters such as serotonin and dopamine which are vital in regulating your mood. It is also important in the regulation of cortisol, the stress hormone, by reducing the levels in your body and supporting the recovery processes. With less stress and a more balanced mood, you will sleep better.

Other Benefits That Support Better Sleep

Experience the Benefits of NAD+ At Home

You don’t have to go all the way to NAD therapy in London or anywhere else to gain the benefits. For improved sleep, more energy and pain and ache reduction, try the NAD+ injection pen.

For more information about NAD+ and our range of wellness products, take a look at our online shop today.

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