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NAD+

Is NAD Better Than Collagen?

Georgina Glenn, Registered Nurse December 1st 2025

Is NAD Better Than Collagen?

Is NAD better than collagen? Both are widely used, heavily discussed and have loyal followings. But is one really better than the other? The short answer is no, and they’re not actual competitors, as they both work in different ways. 

Deciding which one is better depends on what you’re trying to support. So, in this guide, we break down NAD and collagen so you can learn what each does, how they differ, why they might be helpful, and why so many people rely on them as part of their anti-ageing plan.

What Collagen Does

Collagen is one of the most abundant proteins in the human body. It provides structure, elasticity and strength to tissues including the skin, joints, tendons and even parts of the digestive system. 

Skin Elasticity and Hydration

Collagen is a key part of the skin’s dermal layer and contributes to firmness and elasticity. As we age, natural collagen production decreases, and this is why so many of us experience fine lines, thinning skin and decreased plumpness. 

For this reason, many people turn to collagen supplements for skin ageing support – especially for appearance-related outcomes. 

While research shows us that the body breaks down ingested collagen into amino acids rather than using it intact, regular use is believed to support the body’s supply of collagen, which is needed for skin structure and repair. 

Skin, Joint and Tendon Support 

Collagen also plays an important role in maintaining the structural integrity of joints and connective tissue. Therefore, those who want to support their mobility or address age-related joint stiffness may look to include collagen peptides in their routine. 

Fundamental Structures

Most importantly, collagen is a structural protein. Your body uses it to repair, rebuild and maintain tissues. Think of your body as a home, collagen is the wood, bricks and plaster giving your body its shape, strength and support. 

Is NAD Better Than Collagen
Image showing NAD+ Lipsomal being emptied out of the jar

What NAD Does

NAD (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell. Unlike collagen, it doesn’t work as a building block but instead gives your body and cells the energy needed to function properly. 

Energy Production

One of NAD’s most important roles is supporting mitochondrial function. Mitochondria are often called the powerhouse of cells and use NAD to convert food into usable energy. NAD levels decline as we age, and we know this can affect how efficiently cells produce energy. This is why many people use NAD supplements to boost energy and revert tiredness and age-related changes. 

Where collagen affects the body’s structure, NAD affects the power supply that keeps everything running smoothly.

DNA Repair 

Every day our cells experience damage due to metabolic processes, UV exposure and other environmental factors. NAD helps to fuel certain enzymes involved in our DNA repair. This is just one reason that it has gained popularity for longevity. 

Mitochondrial and Metabolic Health

NAD has a role in mitochondrial function, metabolic pathways, cellular stress response and cellular ageing. This all influences how cells function and look structurally. This is why NAD is positioned as deep support rather than just a physical building-block supplement. 

Healthy Ageing

While collagen is widely used in beauty and joint support, NAD relates to metabolic and cellular ageing. It doesn’t replace the effects of collagen but does work at a different biological level. Again, if we take the house metaphor. Your body is the home, but NAD is the electricity, powering systems that keep the structure functioning. 

NAD vs Collagen: Anti-ageing Supplements Comparison

This is one of the most common questions, and the answer is clear. Neither is better as they both support different aspects of health. They are used for different reasons, helpful for different outcomes and work in entirely different ways. 

Think of collagen as the building blocks:

●      Providing structural protein

●      Supporting skin elasticity

●      Aiding connective tissue strength

●      Helping maintain hair, nails and joints

●      Working at the tissue level

And NAD as the cellular engine:

●      Powering mitochondrial energy production

●      Supporting metabolic pathways

●      Fuelling DNA repair systems

●      Maintaining cellular resilience

●      Working at the deep cellular level

With this in mind, if you’re focused on skin ageing and joint comfort, collagen may be a better option as it supports the physical structure of your skin. But if you are concerned about ageing at a cellular level, NAD is often the better choice. 

For most people, however, the most effective approach is not to choose one but to understand how they complement each other.

Collagen Vs NAD: When Each May Be Helpful

Below you’ll find a practical breakdown to help you decide which supplement aligns with your specific needs and goals. 

Choose collagen if you’re focused on:

●      Improved skin elasticity 

●      Better skin hydration

●      Joint comfort or mobility support

●      Improved hair and nails

●      An easy-to-add dietary protein source

Those who are concerned with visible signs of skin ageing, or who are engaging in physical activity affecting their joints, often find collagen helpful.

Choose NAD if you’re focused on:

●      Healthy energy levels

●      Cellular ageing support

●      Mitochondrial support

●      Help maintain vitality as you age

●      Support for recovery from stressors that affect cellular health

●      Help maintain balanced oxidative and inflammatory responses

●     Assist natural cellular repair and resilience

●     Support healthy metabolic function across key body systems

Alternatively, those in search of deeper-level wellness support often prefer NAD. 

When to Consider Using Both

As mentioned, both collagen and NAD can be used as part of the same wellness routine. Collagen supports the outside and connective tissues, while NAD supports the inside. When used together, they create a complete and all-encompassing anti-ageing support system – one that addresses both the structural and cellular foundations of health.

liposomal nad+ capsule supplements 90 day
NAD+ pen product imagery

Why Many People Combine NAD and Collagen

A multi-layer approach to healthy ageing and health in general has become increasingly common. This is because ageing isn’t caused by a single process. Instead, it involves:

●      Changes in cell signalling

●      Declining collagen production

●      Decreased NAD levels

●      Increased cellular stress

●      Reduced mitochondrial efficiency

●      Structural changes in skin and connective tissue

Because collagen and NAD address different parts of this process, many people find that when they use both, it helps to maintain the healthy structure of their body. What’s more, nutrition, sleep optimisation, strength training and stress-management techniques can bring further benefits. 

Professional Guidance Matters

It’s important to note that individual needs vary, and this means that some people may benefit more from collagen while others may see greater results from NAD supplementation. That’s why a professional and personalised approach to treatment is key. 

Working with a professional can help determine:

●      The best starting point based on your goals

●      Whether NAD+, NMN or NR supplementation is appropriate

●      How to combine cellular and structural support effectively

●      What dosage or delivery method may be ideal

●      How to integrate supplements into a larger anti-ageing plan

This is where services like NAD+ At Home come in, providing essential guidance on using NAD therapy safely and effectively while offering personalised recommendations based on your age, lifestyle, and wellness goals.

Ready to Build a Personalised Anti-ageing Treatment Plan?

In the debate over NAD vs collagen, there isn’t a single winner. And the answer truly depends on your personal goals. Plus, don’t forget that for many people, the most effective strategy is to include both as part of a tailored plan.

If you’re looking to explore what NAD+ can do for you, check out our product range today.

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