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Does NAD+ Reverse Ageing?

Georgina Glenn, Registered Nurse July 3rd 2025

Does NAD+ Reverse Ageing?

People are living longer and more healthily. Worldwide life expectancy is increasing, almost doubling from 32 years in 1900 to over 71 now.

With this increased health and modern science awareness, there has been a rising interest in anti-ageing therapies.

In this new frontier is NAD+.

NAD+ and anti-ageing have become closer linked topics as the effects of this coenzyme are further explored and more widely known. Celebrities, athletes and biohackers all swear by NAD+ and its many benefits.

Well, does NAD reverse ageing? Find out here!

What Is NAD+ and Why Does It Decline With Age?

If you interested in cellular ageing reversal in the UK, you need to know about NAD+. It stands for nicotinamide adenine dinucleotide and is a coenzyme that is found in every cell in your body.

NAD+ is involved in countless processes of the body, aiding in energy production, mitochondrial function, DNA repair, cellular communication and aiding in muscle and tissue repair.

Unavoidably, NAD+ levels begin to decrease as you age. This happens mainly because enzymes such as CD38 and PARPS increase, consuming and breaking down NAD. Your body also stops being able to synthesise NAD as efficiently, meaning levels begin to drop.

This drop in NAD+ levels in the body can contribute to fatigue, slower recovery, and other ageing symptoms like skin tissue damage.

What Is NAD+ and Why Does It Decline With Age?

The Science Behind NAD+ and Ageing

There is plenty of science to explain how NAD+ and ageing are connected.

  • Sirtuins: NAD+ may help with healthier ageing as they are involved in the activation of sirtuins. These are groups of proteins that are sometimes referred to as longevity genes. Sirtuins are involved in DNA repair, anti-inflammatory responses and combating oxidative stress. All this can help to reduce the effects of ageing.
  • DNA Repair: NAD+ supports other enzymes such as sirtuins and PARPs to repair DNA, giving them the energy they need to get the job done. Poor DNA repair could contribute to ageing and leave you more susceptible to diseases.
  • Oxidative Stress: Oxidative is the imbalance of free radicals and antioxidants in your body. This imbalance leads to cell damage and inflammation. NAD+ is involved in producing NADPH, a molecule that plays a vital role in creating antioxidants. This means there is less cell damage and better cell function.
  • Mitochondrial Health: Mitochondria are the powerhouses of cells. Mitochondrial dysfunction can lead to inflammatory responses, increased oxidative stress and reduced energy production. All this contributes to more visible symptoms of ageing.

Key NAD+ Research

All of the evidence around the benefits of NAD+ is becoming more known due to the research and findings of people such as Dr David Sinclair. He is a Harvard professor who wrote a bestselling book “Lifespan” that looks at the science behind NAD+ and epigenetic ageing – that epigenetic information that is lost could be reversed, resulting a rejuvenation of cells and tissue.

Dr Nicola J Conlan has written about the role of NAD+ in regenerative medicine and research from Professor Mathias Ziegler at the University of Bergen has looked at how NAD+ and mitochondria are related to ageing.

Can NAD+ Reverse Ageing?

So, does NAD+ reverse ageing?

NAD+ therapy cannot turn back time or make you biologically younger overnight. What it can do is support cellular functions that slow down the ageing process and make your body work more efficiently.

This study from 2024 and many others, with more research being dedicated to the subject of NAD, seem to suggest that boosted NAD+ levels may bring about improvement in energy levels, cognition, skin quality, and metabolic function.

All this can have a rejuvenating effect on you, lessening the impact of ageing.

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Can NAD+ Reverse Ageing?

Realistic Expectations and Benefits

There are a wide range of benefits you can get from NAD+ but you have to remember that it can’t turn you into Superman or Wonder Woman. NAD+ treatments should be part of living a healthier lifestyle. Eating well and exercising can help increase NAD levels in your body and support age-related decline.

Here’s what you may gain from having increased NAD+ levels in your body:

  • Boosted energy and mental clarity: As NAD is vital to cell energy and efficiency, this leaves you feeling more energised. It can help with cognitive function, and memory and may protect against problems such as dementia.
  • Improved sleep and mood: NAD+ will help regulate your circadian rhythm, giving you better-quality sleep. Poor mood is often down to feeling tired and run down, with a more regular sleeping pattern you will find your mood improving. NAD+ may also help with mood regulation by increasing dopamine and serotonin levels.
  • Healthier skin and recovery rates: NAD+ helps with DNA repair, reducing sun-induced skin damage. The support it gives to mitochondrial function and energy production will lead to healthier skin cells and revitalisation of tired cells.

Delivery Methods: How to Get NAD+

NAD+ treatments and supplements come in many forms. They all can help so when deciding you should pick the method that feels most comfortable for you.

IV Therapy

NAD IV therapy in the UK is becoming more popular due to celebrity endorsements. This is a highly effective and efficient way to boost NAD+ levels as it is the most direct and bioavailable method. Via this method, the supplement bypasses the digestive system and is absorbed directly into the bloodstream with no dilution.

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IV Therapy

Supplements vs. Infusions

You can take oral supplements of NAD+ in the form of liposomal capsules. Compared to infusions, oral supplements can be more easily fitted into your daily routine, are cheaper and there is a low chance of side effects.

Supplements vs. Infusions

At-home Delivery

At-home injection is a potential middle ground, offering the bioavailability of IV therapy and the convenience of oral supplements. You can get medical supervision for at-home delivery, attending injection training to ensure you are being safe and letting your GP know what you are doing so they can offer guidance.

At-home Delivery

Who Might Consider NAD+ Therapy?

Everyone could profit from NAD+ longevity treatment, but certain people may be more likely to show signs that they need to boost their NAD+ levels.

People in their 30s+ Noticing Signs of Ageing

NAD levels start to decline after turning 30. If you are in this age bracket and have begun to notice signs of ageing, then boosting your NAD+ levels with treatment or supplements can help your body perform more efficiently.

Busy Professionals

If you are often on the go and want to improve your performance at work and beyond, NAD+ treatment can help your body and mind work closer to its capacity.

People Recovering

If you are suffering from burnout, are always feeling stressed or recovering from illness, NAD+ can help. It’s involved in major processes in the body and boosted levels can help your body recover more effectively.

Those Looking to Optimise Long-Term Health and Vitality

The biohacking scene is becoming larger and more people are health conscious. You don’t need to break the bank to try and optimise your long-term health and grow older whilst not compromising too much on your vitality and physical and mental capabilities.

Support Healthy Ageing with NAD+ At Home

Ageing is a part of life, but there is a better way to do it.

NAD+ has many benefits and supplements might be just what you need to help optimise your health and body. Check out our online shop to see the NAD+ At Home range of wellness products.