The Benefits of Liposomal NAD+

In recent decades, modern life has transformed dramatically, bringing with it a wide range of challenges for our heath and wellbeing. From environmental toxins and oxidative stress to processed foods and chronic inflammation, there are plenty of new-world health risks which may be increasing cellular ageing and depleting our body’s reserves of important natural molecules and nutrients.

Fortunately, there’s plenty of promising research into NAD+ supplementation and how it may play a role in halting or even reversing cellular ageing, while more generally improving the efficiency of our biological functions.

Although NAD+ injections and IV therapy are the most proven methods for increasing NAD+ within our bodies, NAD+ capsules have a come long way, too.

The key is the use of liposomes and liposomal technology to ensure much need nutrients arrive at our cells unharmed and ready to make an impact.

Here, we’ll explore exactly what Liposomal NAD+ is and how liposomes (particularly our SAIFx® technology) help maximise the bio-availability and efficiency of NAD+ within our bodies.

What is Liposomal NAD+?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme essential to every living cell in your body. This molecule plays a role in hundreds of bodily processes, from energy production in our mitochondria to DNA repair and cellular regeneration.

Unfortunately, by the time we reach middle age, studies have shown NAD+ levels drop to approximately half those of available in our younger days, a decline that correlates with the onset of many age-related concerns.

What are liposomes?

Liposomes are like a microscopic version of an Uber Eats driver! They help our bodies move nutrients around, particularly allowing our cells to receive the molecules they require for a whole host of bodily functions.

For those of a more scientific background, liposomes are “spherical vesicles composed of phospholipids” and are the same molecules that form our cell membranes. We’ll explore this in a little more detail but for the full lowdown, check out our guide to what liposomal means.

These intelligent units house active ingredients and shield them from the harsh acidic environment of digestive system, enabling absorption into your bloodstream and cells.

As per naitre.com, “liposomes are spheres made of a dual lipid bilayer with an aqueous core where the active ingredients are held. They can be made in the laboratory starting from naturally derived lipids such as phosphatidylcholine-enriched lipids. This means that they will have minimal toxicity since the body won’t recognised them as “foreign” agents.”

While it’s all quite scientific, there are some important advantages of using liposomes for drug delivery, also reported by naitre.com:

1. Enhanced uptake and bioavailability

2. Biocompatibility

3. Biodegradability

4. Low toxicity

5. Possibility to tailer target-specific delivery

The Science Behind Our SAIFx® Encapsulation Technology

Oral supplements face a host of challenges when travelling through your digestive system. Many nutrients that supplements are supposed to increase get broken down by acid in the stomach or metabolised by the liver before reaching their target. Simply, the harsh environments of our stomach can reduce the efficacy of supplements which are ingested without protective measures.

That’s why liposomal technology is important. By improving the delivery of supplements, we can protect the active ingredients of supplements as they pass through the stomach and into the intestines.

Put simply, this increases the bio-availability of active ingredients and helps ensure they reach their required destination, in as close to full strength as possible, ready to play their role in improving our health. As shown below, liposomes attach to your cell membrane and allow the active ingredient they contain to be fully ingested by the cell it targets.

Bioavailability studies have shown liposomal supplements demonstrate up to 46 times greater bioavailability compared to non-liposomal alternatives. This dramatic difference means your body can actually utilise what you’re taking, rather than simply passing it through your system.

It’s worth noting here that liposomes aren’t anything new. In fact, the body naturally transports NMN (a key NAD+ precursor) through the bloodstream using extracellular vesicles that are themselves liposomes.

Liposomal NAD+, therefore, may mimic the body’s own transport system, enhancing uptake and working alongside your body’s natural processes.

The potential benefits of NAD+ supplementation

So, now we know how liposomal technology can improve the efficiency of supplements, let’s explore how NAD+ may impact our overall health.

First, it’s important to raise that while scientific evidence for the benefits of NAD+ supplementation continues to increase, more studies and clinical trials are required to truly determine its impact on our health and wellbeing. The potential benefits shared below are just that: potential and as yet unproven. However, what has so far been tested, in both animal and human trials, is promising and shows potential for:

1. Increased cellular energy

NAD+ plays a key role in energy production. It’s an essential part of how our mitochondria convert nutrients into ATP, a molecule that acts as the main energy currency for cells in living organisms. Users of NAD+ regularly report sustained energy throughout the day without the crashes typically associated with other energy sources, such as caffeine and other stimulants.

2. Improved metabolic health

NAD+ supplementation has been shown to boost insulin sensitivity, reverse mitochondrial dysfunction and support healthy metabolic function. These improvements help your body process nutrients more efficiently. Read our article to learn more about the role of NAD+ on metabolic health.

3. Better cognitive support and brain function

Increasing levels of NAD+ has shown significant neurological benefits in numerous animal trials. While more research is required, particularly on the impact to the human biological makeup, those animal studies show positive signs for cognition and nerve regeneration. What’s more, we often see enhanced mental clarity and focus frequently reported as benefits of NAD+ treatments.

4. Increased cardiovascular health

The heart demands extraordinary amounts of cellular energy. NAD+ shows promise for cardiovascular support, with studies demonstrating that “decreased NAD+ levels lead to inadequate ATP production and increased susceptibility to heart failure.” As research continues, scientists are exploring how to best increase NAD+ levels to alleviate heart failure.

5. Healthy ageing

NAD+ is being explored heavily by science and health leaders due to its crucial nature for cellular processes like DNA repair and energy production, both linked to ageing. Studies in animals show promising results while human studies are ongoing.

Summary

Liposomal NAD+ may support your body at the cellular level. Whether you’re seeking to enhance your energy reserves, improve brain function, optimise metabolic health or invest in long-term vitality, liposomal NAD+ could provide the bioavailable nutrition your cells need to thrive.

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